Abstract
The full potential of rhodium (II) -catalyzed intramolecular C-H insertion reactions of α-diazo carbonyl compounds as a powerful tool for the construction of both carbocycles and heterocycles has been developed by variation of the bridging ligands of the dirhodium (II) catalysts : (1) Dirhodium (II) tetrakis (triphenylacetate) featured by the steric bulk of the bridging ligands on the rhodium has been demonstrated to exhibit an exceptionally high order of selectivity for C-H insertion into methylene over methine on a cycloalkane ring as well as for aromatic substitution over aliphatic C-H insertion. (2) Dirhodium (II) complexes incorporating N-phthaloyl- (S) -amino acids as bridging ligands have proven to be the chiral catalysts of choice for allowing high levels of differentiation of enantiotopic methylene C-H bonds and enantiotopic benzene rings, affording optically active cyclopentanone, 2-azetidinone, and 2-indanone derivatives in up to 80%, 96%, and 98% ee, respectively.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
