Abstract
SIRT1 polymorphisms have previously been associated with depressive and anxiety disorders. We aimed at confirming these earlier findings and extending the analyses to seasonal variations in mood and behavior. Three tag single-nucleotide polymorphisms (SNPs) were selected to capture the common variation in the SIRT1 gene. 5910 individuals (with blood sample, diagnostic interview, self-report of on seasonal changes in mood and behavior) were selected from a representative Finnish nationwide population-based sample. Logistic and linear regression models were used to analyze the associations between the SNPs and depressive and anxiety disorders, metabolic syndrome (EGIR criteria) and its components, and health examination measurements, Homeostasis Model Assessments, and diagnoses of type 2 and type 1 diabetes. SIRT1 rs2273773 showed evidence of association with seasonal variation in weight (C-allele, OR = 0.85, 95% CI = 0.76–0.95, p = 0.005). In addition, our study gave further support for the association of SIRT1 gene with depressive disorders (rs3758391) and diastolic blood pressure (rs2273773).
Highlights
Many recent studies have focused on sirtuin 1 (SIRT1) in relation to metabolism, insulin resistance, cancer, and longevity [1,2,3]
The selection (n = 5910) included individuals who had given blood samples, taken part to the Munich-Composite International Diagnostic Interview (M-CIDI) [15] and filled in the self-report on seasonal changes in mood and behavior adapted from the Seasonal Pattern Assessment Questionnaire (SPAQ) [16]
SIRT1 rs3758391 T allele showed nominally significant associations with depressive disorders (OR = 1.19, 95% CI of 1.01 to 1.40, p = 0.040, see Table 3), metabolic syndrome (OR = 0.88, 95% CI of 0.80 to 0.97, p = 0.01, see Table 3), insulin resistance index and blood glucose
Summary
Many recent studies have focused on sirtuin 1 (SIRT1) in relation to metabolism, insulin resistance, cancer, and longevity [1,2,3]. SIRT1, which is a histone deacetylase, participates through its deacetylase activity for tens of substrates in the coordination of a range of cellular functions, such as cell-division cycle, response to DNA damage, apoptosis, and autophagy. There is an earlier report on SIRT1 in metabolic syndrome, where there was no significant association [4]. Genetic variations in SIRT1 have been associated with depressive [5] and anxiety [6] disorders. Both common and rare variations in SIRT1 in humans were
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