Abstract
From the methanolic extract of Orthosiphon stamineus, four novel highly oxygenated isopimarane-type diterpenes named siphonols A–D ( 1– 4) and a novel biogenetically interesting norisopimarane-type diterpene named siphonol E ( 5) were isolated. The new compounds 1– 3 and 5 showed more potent inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells than a positive control N G-monomethyl- l-arginine ( l-NMMA). Siphonols A–E ( 1– 5) represent the first examples of isopimaranes oxygenated at C-20.
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