Single versus double intrauterine insemination (IUI) in women with idiopathic subfertility

Abstract

Objective: To compare pregnancy rates per treatment cycle of controlled ovarian hyperstimulation (COH) among patients receiving COH with single IUI with patients receivingtwo IUIs and those who practice regular sexual intercourseMaterials & Methods: All of the 300 studied women were diagnosed as idiopathic infertility and their husbands were having normal seminogram. They were divided into 3subgroups each 100 women:G1; received induction of ovulation and advised to have anormal and frequent regular intercourse during the period around ovulation. G2; receivedinduction of ovulation and subjected to IUI after 30 hours of HCG injection which isgiven in a dose of 10,000 iu intramuscular based on ultrasonic monitoring of folliculogenesis. G3; received induction of ovulation and subjected to intrauterine inseminationafter 30 hours and 42 hours of HCG injection.Results: A total of 300 patients were randomized among groups1, 2, 3 (100 women pergroup) cycles). Data analysis demonstrated no significant differences among 3 groupswith respect to age, Body mass index, Mean ovarian volume ,LH ,FSH, PRL ,E2 or Testosterone levels (table -1). However, Our result showed a pregnancy rate 2% in the firstgroup, 10% in the second group and 11% in the 3rd group with statistically significantdifference between single and also double IUI and normal frequent intercourse withoutinsemination but no statistical difference between single and double IUI as regards pregnancy rate (table -2)Conclusion: We concluded that double insemination not beneficial more than singleinsemination in spite of increasing the number of motile sperm.