P20.12: Double IUI (intrauterine insemination) in cases with high pre hCG perifollicular PSV for better pregnancy rates: a randomized study of 350 IUI cycles

Abstract

To assess if the patients with pre hCG high perifollicular PSV values, would benefit with a double IUI, instead of single IUI. A randomized prospective study was done of 350 IUI cycles who were stimulated by either CC or rFSH (recombinant FSH) or Letrozole with rFSH and showed a pre hCG perifolliclular PSV of 15cms/sec. Single IUI was done at 36 –38 hours after hCG injection and in double IUI cases the IUI were done at 12–14 hours and 36–38 hours. With CC stimulated cycles when perifollicular PSV was 15–20, single IUI gave nearly similar conception rates with both single and double IUI. With PSV 20 –25 cms/sec, double IUI showed higher conception rates than single IUI. But when was PSV > 25, conception rates were very low with single IUI than with double IUI. With rFSH cycles with PSV 15–20, conception rates were comparable with both single IUI and double IUI but with PSV > 20, the conception rates were significantly better and with PSV > 25, the pregnancy rates with single IUI were significantly low. Same was the case with letrozole + rFSH cycles. In all cases with PSV > 25 cms/sec on the day of hCG, a double IUI gives better pregnancy rates, but this limit lowers to PSV 20, when it is a rFSH cycle.