Abstract
Long interspersed nuclear element 1 (LINE-1 or L1) is an intragenomic parasitic element that constitutes approximately 20% of the human genome. It amplifies within the host genome by copying its RNA transcript into genomic DNA through a process called retrotransposition. L1 encodes two proteins, ORF1p and ORF2p, that associate with their encoding transcript to form a ribonucleoprotein complex, an essential intermediate in L1 retrotransposition. Mechanistic understanding of L1 retrotransposition is sparse, particularly with respect to the function of ORF1p, a coiled coil (CC)-mediated homotrimeric nucleic acid (NA) chaperone that binds single-stranded NA and mismatched oligonucleotide duplexes with high affinity.
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