Abstract
Single nucleotide polymorphisms (SNPs) in human zinc ribbon domain containing 1 antisense RNA 1 (ZNRD1-AS1) have been associated with cancer development. In this meta-analysis, we more precisely estimated the associations between three expression quantitative trait loci SNPs in ZNRD1-AS1 (rs3757328, rs6940552, and rs9261204) and cancer susceptibility. The data for three SNPs were extracted from eligible studies, which included 5,293 patients and 5,440 controls. Overall, no significant associations between SNPs in ZNRD1-AS1 (rs3757328, rs6940552, and rs9261204) and cancer risk were observed. However, in further subgroup analyses based on cancer type, we found that the A allele of rs3757328 increased the risk of some cancer in both allele contrast (OR = 1.15, 95% CI = 1.05 – 1.25) and recessive models (OR = 1.79; 95% CI = 1.33 – 2.41). The A allele of rs6940552 and the G allele of rs9261204 also increased the risk of some cancer in an Asian population in allele contrast (OR = 1.17, 95% CI = 1.08 – 1.26, and OR = 1.25, 95% CI = 1.16 – 1.34, respectively) and recessive models (OR = 1.44, 95% CI = 1.18 – 1.77, and OR = 1.49; 95% CI = 1.23 – 1.80, respectively). Thus, rs3757328, rs6940552, and rs9261204 in ZNRD1-AS1 are all associated with increased some cancer risk in an Asian population.
Highlights
Long noncoding RNAs are a class of RNAs greater than 200 nucleotides in length that are not translated into proteins [1]
We evaluated the effects among the subgroups, and found that the A allele of rs6940552 significantly increased cancer risk (HCC, lung cancer, and bladder cancer) except cervical cancer (Figures 2A and 2B, recessive model: Odds ratio (OR) = 1.44; 95% confidence intervals (CI) = 1.18–1.77, P = 0.774 for the heterogeneity test, I2 = 0.0%; additive: OR = 1.17; 95% CI = 1.08–1.26, P = 0.972 for the heterogeneity test, I2 = 0.0%)
We analyzed the associations between three Single nucleotide polymorphisms (SNPs) in zinc ribbon domain containing 1 (ZNRD1)-AS1 and cancer risk
Summary
Long noncoding RNAs (lncRNAs) are a class of RNAs greater than 200 nucleotides in length that are not translated into proteins [1]. The expression of lncRNAs is cell type- and tissue-dependent, which distinguishes them from protein-coding genes [2]. The secondary structures of the lncRNAs can dictate their functions in various cellular processes and diseases [3]. Some lncRNAs activate the oncogenic signaling pathways to drive cancer phenotypes [4]. LncRNA HULC promotes the epithelialto-mesenchymal transition phenotype and tumorigenesis in both pancreatic and gastric cancer cells [5, 6]. Single nucleotide polymorphisms (SNPs) in lncRNAs can promote cancer development and progression. Expression quantitative trait loci (eQTLs) in the lncRNA
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
