Abstract
Polymorphisms in the HOX transcript antisense intergenic RNA (HOTAIR) have been recently associated with susceptibility to different cancers. Here, a meta-analysis was performed to derive a more precise estimation of the involvement of HOTAIR polymorphisms in cancer development. Data from cases (n = 7,772) and controls (n = 9,075) were extracted from eligible studies (n = 10) identified in a comprehensive literature search conducted in PubMed, Embase, and the Web of Science databases through January 20, 2016. Overall, association between polymorphism rs920778 and increased cancer risk was significant in allele contrast (odds ratio (OR) = 1.239, 95% confidence interval (CI) = 1.032 - 1.487) and recessive models (OR = 1.614, 95% CI = 1.082 - 2.406). In subgroup analysis based on ethnicity, a significant association between polymorphism rs920778 and cancer susceptibility was observed in Asians under all models, but was most compelling under recessive (OR = 2.128, 95% CI = 1.417 - 3.197) and homozygous models (OR = 2.764, 95% CI = 2.221 - 3.440). Subgroup analysis by cancer type revealed a significant association between polymorphism rs4759314 and susceptibility to gastric cancer in allele contrast (OR = 1.262, 95% CI = 1.073 - 1.486), dominant (OR = 1.280, 95% CI = 1.060 - 1.547), and heterozygous models (OR = 1.288, 95% CI = 1.057 - 1.570). In conclusion, the results indicated that HOTAIR polymorphism rs920778 was more generally associated with cancer risk, particularly in Asians, while rs4759314 was a risk factor for gastric cancer.
Highlights
Long non-coding RNAs are defined as transcribed RNA molecules that are longer than 200 nucleotides and not translated into proteins [1]
The results indicated that HOX transcript antisense intergenic RNA (HOTAIR) polymorphisms are associated with increased cancer risk, but mainly in stratified analysis based on ethnicity and cancer type
We performed a metaanalysis using data from available cases (n = 7,772) and controls (n = 9,075) in the literature to date to provide further evidence that HOTAIR polymorphisms rs4759314 and rs920778 are associated with cancer risk
Summary
Long non-coding RNAs (lncRNAs) are defined as transcribed RNA molecules that are longer than 200 nucleotides and not translated into proteins [1] Their function was initially unclear, lncRNAs are known to have critical roles in the regulation of gene expression through transcription, processing of small RNAs, and epigenetic modification as well as other regulatory functions [2, 3]. As key components in gene regulatory complexes, lncRNAs contribute to the activation or inhibition of expression of genes involved in diverse normal cellular processes, such as proliferation and apoptosis Many of these same processes are corrupted in cancer, and deregulated lncRNA expression has been linked to development of the disease [3,4,5,6]. HOTAIR is a 2158-nucleotide lncRNA transcribed from the antisense strand of the HOXC gene which is located on chromosome www.impactjournals.com/oncotarget
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