Abstract
Single nucleotide polymorphism array profiling of adrenocortical tumors: evidence for an adenoma carcinoma sequence?
Highlights
Adrenocortical tumors consist of highly prevalent adenomas (ACA) and rare carcinomas (ACC), which both can be either endocrinologically silent or hormonally active
We here provide for the first time a genome-wide highresolution overview of chromosomal changes in a large series of adrenocortical tumors, including adenomas and carcinomas
In a previous pilot study we already observed in a small group of benign cortisol-secreting tumors frequent CN gains in newly reported chromosomal regions (i.e. 8q24.3, 11p15.5, Xq28) and promising candidate genes or pathways potentially involved in early tumorigenesis [40]
Summary
Adrenocortical tumors consist of highly prevalent adenomas (ACA) and rare carcinomas (ACC), which both can be either endocrinologically silent or hormonally active. We reported novel genes (i.e. HRAS, EPHA7, and SGK1) and pathways (i.e. Notch signalling pathway) that could be involved in early tumorigenesis [40] Another recent study on childhood adrenocortical tumors using SNP array profiling identified some amplified oncogenes and deleted tumor suppressor genes and demonstrated different oncogenic routes [41]. We used high-resolution SNP microarrays to investigate a larger series of benign and malignant adrenocortical tumors with the major aim to identify new candidate genes that could be suggestive for an adenoma-carcinoma sequence (i.e. alterations common between ACA and ACC). We intended to recognize new potential markers of malignancy or prognostic factors for ACC
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