Abstract
In broiler chickens, the intensive selection for growth rate, feed efficiency, body composition (breast muscle weight) traits in the last decades was successful. To improve economically important characteristics, it is possible to use molecular markers associated with meat production traits. The aim of this study was to examine genotype polymorphisms in ROSS 308 broilers for thyroid hormone responsive Spot14α, insulinlike growth factor 1 (IGF1), IGF-binding protein 2 (IGFBP2), somatostatin (SST) and prolactin (PRL) genes. A further goal of this investigation was to study the relationship between the polymorphisms and phenotypic characteristics.
 In the investigated broiler population, the frequency for CC homozygous genotype was 0.77 in Spot14α (AY568628), AA homozygous genotype was 0.80 in IGF1 (M74176), GG homozygous genotype was 0.85 in IGFBP2 (U15086), DD homozygous genotype was 0.60 in PRL (FJ663023 or FJ434669). Only the AA homozygous genotype was found in SST (X60191). Chickens with AC genotype in Spot14α, and with GG genotype in IGFBP2 had higher body weight (BW) and carcass weight (CW), compared to CC and GT genotypes. However, the differences were not significant (P>0.05). There was significant association (P<0.05) between PRL genotypes and body and carcass weight, where chicken with homozygous DD surpassed individuals with homozygous II genotypes.
Highlights
The intensive application of selection methods in broiler chicken has successfully increased growth rate, feed efficiency, carcass yield, and breast muscle percentage
Spot14α is maintaining a connection between thyroid hormone concentrations and growth (Cao et al 2007, d’André Hirwa et al 2010)
Feathers samples were collected from the individuals for the identification of Spot14α, insulinlike growth factor 1 (IGF1), IGF-binding protein 2 (IGFBP2), SST, PRL genotypes
Summary
The intensive application of selection methods in broiler chicken has successfully increased growth rate, feed efficiency, carcass yield, and breast muscle percentage. Allele frequency analyses are often used to identify potential candidate genes and polymorphisms, and are important for the selection of advantageous genotypes. Application of molecular markers associated with meat and egg production is a potential tool to improve production yields. The thyroid-hormone responsive Spot gene ( known as THRSP) was identified as duplicated polymorphic paralogs in chicken, namely Spot14α and Spot14β. Spot14α is maintaining a connection between thyroid hormone concentrations and growth (Cao et al 2007, d’André Hirwa et al 2010). Expression of Spot14α mRNA is regulated by thyroid hormone status (Wang et al 2004)
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