Abstract
The nuclear pore complex (NPC) is the gatekeeper of the nucleus that regulates the flow of all molecules across the nuclear envelope. Remarkably, this ∼40 nm wide pore is capable of efficient and fast transport while remaining highly selective. The dense central channel of the NPC is filled with a dynamic spaghetti-like mesh of intrinsically disordered proteins containing FG repeats (FG-Nups). While small molecules can freely pass this barrier, large biomolecules (>40 kDa) require specific transporter proteins.
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