Abstract
The ε4-allele isoform of apolipoprotein E (ApoE4) is the major genetic risk factor for Alzheimer's disease (AD). ApoE transports cholesterol as a component of lipoproteins in the blood and brain. Evidence suggests that a single point mutation in ApoE, which differentiates one isoform from another, may alter its structure and, contextually, its lipid binding ability. Identifying the conformations of lipid-free and lipid-bound ApoE4 may provide insights into the role of ApoE4 structure in Alzheimer's disease.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
