Abstract
Islet amyloid polypeptide (IAPP) is a 37 aa peptide that accumulates and fibrilizes in insulin-secreting β-cells in patients with type II diabetes. However, while pancreatic IAPP fibrils are a hallmark of the disease, their soluble oligomeric precursors are most potently correlated with their pathological function. IAPP oligomers (IAo) are thought to disrupt homeostasis through interactions with the proteasomal pathway and direct binding to physiological membranes, leading to membrane-poration and mitochondrial leakage.
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