Abstract
We present a single fiber reflectance confocal microscope with a two dimensional MEMS gimbaled scanner. Achieved lateral and axial resolutions are 0.82 mum and 13 mum, respectively. The field of view is 140 x 100 mum at 8 frames/second. Images and videos of cell phantoms and tissue are presented with sub-cellular resolution.
Highlights
Confocal microscopy is an established optical imaging technique used to obtain highresolution images of cells [1]
Confocal reflectance microscopy has been demonstrated to have significant potential to detect sub-cellular morphologic changes and alterations in tissue architecture associated with the earliest stages of cancer [2, 3]
Both coherent [4] and incoherent [5] optical fiber bundles have been used for en face image formation
Summary
Confocal microscopy is an established optical imaging technique used to obtain highresolution images of cells [1]. Confocal reflectance microscopy has been demonstrated to have significant potential to detect sub-cellular morphologic changes and alterations in tissue architecture associated with the earliest stages of cancer [2, 3]. Translation of this technology for in vivo application using optical fibers and miniature optics will provide clinicians a real-time view of cellular structure, without removal of tissue. Beam scanning across a fiber bundle allows the scanning mechanism to be placed at the proximal end of the optical fibers, where size is unconstrained Both coherent [4] and incoherent [5] optical fiber bundles have been used for en face image formation. Two that are most practical for in vivo endoscopic imaging include spectrally-encoding the fast axis [7] and using micromirrors to scan the beam after exiting the fiber [8, 9]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
