Abstract

The need for antimicrobial prophylaxis in lung surgery has been well documented. Ciprofloxacin, an antimicrobial agent with a very broad spectrum of antibacterial activity, is rapidly absorbed after oral administration, leading to a bioavailability of nearly 85%. Its good tissue penetration, good safety record, and its extremely good chemical stability make this drug a potentially useful agent for perioperative antibiotic prophylaxis. In perioperative antibiotic prophylaxis, it is desirable to achieve the highest possible antibiotic concentrations in plasma and tissues during the surgical procedure' in order to extend the inhibitory concentration to as many potential pathogens as possible. In the present study, the efficacy of a single dose of oral ciprofloxacin 750mg in elective lung surgery was investigated. 1. Materials and Methods

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