Abstract
Mitochondrial calcium uniporter (MCU) forms a macromolecular complex composed by MCU, MICU1, MICU2, EMRE and MCUb, which confers its tissue specificity. However, the native single channel properties and its regulation by kaempferol, a polyphenol known to enhance mitochondrial Ca2+ uptake has never been investigated in left ventricles. Here we aimed to characterize the single channel properties of mice left ventricular MCU complex incorporated in planar lipid bilayer (PLB) and its regulation by kaempferol.
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