Abstract
Publisher Summary This chapter explains single and combined modality therapy in experimental solid tumors. Clinical experience has shown that sequential therapy is the most effective approach in treating patients with solid tumors. Proper sequencing of one or more treatment modalities is one of the promising areas for improving the clinical management of solid tumors. Many protocols in clinical use are empirically designed. There is increasing evidence that human neoplasms are responsive to combined modality therapy; however, delineation of some of the parameters relevant to such therapy can be accomplished only in animal models. Much of the experimental information available pertains to the effects of either chemotherapy alone or radiotherapy alone. Radiotherapy, chemotherapy, immunotherapy, and surgery must be well coordinated to control both the growth of primary tumor and its metastatic dissemination to result in an improvement of the therapeutic efficacy of the more resistant solid tumors in man. Clinical radiotherapy has evolved with a basic approach directed at the eradication of the primary neoplasm by irradiating the tumor tissue to the limits of tolerance. Included in the irradiated area are those adjacent or contiguous normal tissues that may be involved by extension of the neoplasm.
Published Version
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