Abstract
Tuberculosis is common infectious complication in kidney transplant recipients. In immunosuppressed patients, clinical manifestations of tuberculosis are varied and delayed diagnosis and poor clinical outcomes. Especially allograft involvement of tuberculosis can cause allograft loss. In this report, we present the case of 46-year-old man diagnosed disseminated tuberculosis involving allograft kidney successfully treated with maintenance of allograft function.
Highlights
Tuberculosis (TB) is known as a common opportunistic infection in immunosuppressed patients such as organ transplantation recipients
We present the case of 46-year-old man diagnosed disseminated tuberculosis involving allograft kidney successfully treated with maintenance of allograft function
We report a case of lung and allograft kidney TB, successfully treated without graft loss
Summary
Tuberculosis (TB) is known as a common opportunistic infection in immunosuppressed patients such as organ transplantation recipients. Five years after KT, the patient returned to hemodialysis therapy after loss of kidney allograft function due to chronic rejection Ten years ago, he was received second KT from deceased donor. At the time of admission, immunosuppressive therapy consisted of Tac 1.5 mg twice a day (trough level; 6.9 ng/mL), MMF 750 mg twice a day and PN 5mg daily. He diagnosed of cytomegalovirus (CMV) pneumonia by computed tomography (CT) and bronchoscopic biopsy. Thereafter, allograft function was declined gradually and 5 years after TB infection, the patient started to hemodialysis (HD), three times a week He is undergoing HD treatment without infectious complications. Cr: Creatinine; CRP: C-reactive protein; Tac: Tacrolimus; TB: Tuberculosis Figure 3: Timeline of patient’s management and hospital course
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