Abstract

Background: Elevated neurohormones are associated with increased mortality risks in heart failure (HF). We investigated the strategy of simultaneous profiling using both N-ANP (N-terminal atrial natriuretic peptide) and ET-1 (endothelin-1), as compared to either alone, in predicting modes of death in chronic HF pts. Methods: We conducted extended follow-up on 345 NYHA II-IV HF pts and LVEF <40% enrolled in 7 trials/studies between 1996 and 2004 in Belgium. Neurohormones were collected at baseline, and primary causes of deaths were ascertained based on clinical records while blinded to neurohormonal data.

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