Abstract
Purpose/Objective: Whole pelvic irradiation (WPI) followed by a boost to the tumor site is the standard of practice for the radiotherapeutic (RT) management of locally advanced gynecologic cancers. The boost is frequently carried out using intracavitary brachytherapy or occasionally using external beam RT (EBRT) when brachytherapy is not appropriate. The widespread use of EBRT for the boost has been hampered by the problem of target localization and movement. Recently, Low et al have proposed the use of applicator-guided IMRT for the boost after the EBRT. To effectively utilize this applicatorguided technology, we propose to use IMRT simultaneous integrated boost (SIB), which is a single-phase process, to replace the conventional two-phase process involving WPI plus an EBRT or a HDR brachytherapy boost. Radiobiological modeling is used to design appropriate regimes for the IMRT SIB. To demonstrate feasibility, a dosimetric study is carried out on sample patients.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call