Abstract
A simple, accurate, and precise spectrophotometric method was developed for simultaneous estimation of pantoprazole sodium and levosulpiride in capsule dosage form. Simultaneous equation was developed at 290 and 232 nm. The method was found to be linear in the range of 4–12 μg/mL for pantoprazole sodium and 8–20 μg/mL for levosulpiride while accuracy of the method was confirmed by recovery studies of capsule dosage form and was found to be 100.23–100.99% and 100.51–100.94% for pantoprazole sodium and levosulpiride, respectively, in their capsule dosage form. The proposed method was validated and found to be accurate and precise. The method was successfully applied for the estimation of pantoprazole sodium and levosulpiride from their capsule dosage form.
Highlights
Pantoprazole sodium (PNT) is a sodium 5-(difluoromethoxy)-2-[[(3,4-dimethoxy]-2-pyridinyl) methyl]sulfinyl]-1Hbenzimidazole [1] (Figure 1); it is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease [2]
The intraday and interday precision study of the proposed method were carried by measuring absorbance three times on the same day and on three different days for three different concentrations of PNT (4, 8, and 12 μg/mL) and LVS (8, 15, and 20 μg/mL), and the results reported in terms of relative standard deviation (RSD)
The following formulae were established for the estimation of drugs in combined dosage form using simultaneous equation method: CPNT
Summary
Pantoprazole sodium (PNT) is a sodium 5-(difluoromethoxy)-2-[[(3,4-dimethoxy]-2-pyridinyl) methyl]sulfinyl]-1Hbenzimidazole [1] (Figure 1); it is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease [2] It has molecular formula C16H14F2N3NaO4S with molar mass 405.36 g/mol [1]. Levosulpiride (LVS) is an N-[(1-ethyl2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide (Figure 2); it is a new orally effective antipsychotic and a prokinetic agent reported to be a selective antagonist of dopamine D2 receptor activity on both central and peripheral levels. It is an atypical neuroleptic (S)-enantiomer of sulpiride having molecular formula C15H23N3O4S with molar mass 341.43 g/mol. RP-LC method has been reported for the estimation of PNT and LVS in the combined dosage form [16]
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