Simultaneous Electrochemical Determination of Acetaminophen and Dopamine Based on Metal-Organic Framework/Multiwalled Carbon Nanotubes-Au@Ag Nanocomposites

Abstract

In the present work, a novel and selective electrochemical sensor based on copper porphyrin metal organic frameworks (Cu-MOFs) and Au@Ag core-shell nanoparticles decorated multiwalled carbon nanotubes (MWCNT) was designed for the simultaneous determination of acetaminophen (ACOP) and dopamine (DA). The fabrication strategy was accomplished via drop casting of MWCNT-Au@Ag onto the bare glassy carbon electrode (GCE) and then electrodeposition of Cu-MOF on the MWCNT-Au@Ag/GCE. By combining the high surface area (400.54 m2·g−1) of Cu-MOFs with superior conductivity and electrocatalytic properties of MWCNT-Au@Ag nanocomposites, the proposed sensor exhibited the remarkable performance for the electrocatalytic detection ACOP and DA. Under the optimized conditions, Cu-MOFs/MWCNT-Au@Ag/GCE delivered good differential pulse voltammetric response in the ACOP concentration of 1.0∼40, 40∼500 μM and the DA concentration of 0.6∼70, 70∼300 μM with the detection limit of 0.232 μM for ACOP and 0.082 μM for DA, separately. In addition, the designed electrochemical sensor was applied for the determination of ACOP and DA in real samples with reliable and satisfying recoveries (97.88∼104.38% for ACOP and 98.28∼104.40% for DA, respectively) and precisions (2.15∼4.78% of RSD for ACOP and 1.47∼4.46% of RSD for DA, respectively). As expected, these data suggested that the Cu-MOFs/MWCNT-Au@Ag was an excellent potential platform for simple and convenient determination of ACOP and DA.