Simultaneous Electrochemical Determination of α-Tocopherol and Retinol in Micellar Media by a Poly(2,2′-(1,4 Phenylenedivinylene)-bis-8-Hydroxyquinaldine)-Multiwalled Carbon Nanotube Modified Electrode

Abstract

ABSTRACTA novel method was developed for the simultaneous electrochemical determination of α-tocopherol (viatmin E) and retinol (vitamin A) using a poly(2,2′-(1,4-phenylenedivinylene)-bis-8-hydroxyquinaldine)/multiwalled carbon nanotube modified glassy carbon electrode. The simple and rapid voltammetric approach was evaluated for real samples using Triton X-100 to solubilize the analytes in the absence of organic solvent. The calibration graph for α-tocopherol was linear from 8 to 100 µM with a limit of detection of 0.1 µM in the presence of 80 µM retinol. The response was also linear with retinol concentration from 5 to 200 µM with a detection limit of 0.8 µM in the presence of 40 µM α-tocopherol. The developed method was employed for the determination of the vitamins in pharmaceutical products.