Abstract
Mefenamic acid (MNA) treats sports injuries, rheumatoid arthritis, and osteoarthritis. However, improper use/disposal of MNA results in the accumulation of toxic metabolites that may serious disease. The purpose of this study is to fabricate a nano ferrite-based electrochemical sensor for robust, and sensitive determination of MNA. Magnesium ferrite nanoparticles (MgFe4O7-NPs) were synthesized using a green approach using a Mentha leaf extract. The analytical characterization of MgFe4O7-NPs displayed a hexagonal structure and a particle size of less than 21 nm with rough and porous morphology. The synthesized MgFe4O7-NPs were used to fabricate an electrochemical sensor by modifying a glassy carbon electrode (MgFe4O7-NPs/GCE). The cyclic voltammetry (CV) characterization of the electrode confirms excellent redox and diffusion control for electroactive species. Thus, the MgFe4O7-NPs/GCE was used to determine MNA by differential pulse voltammetry (DPV). The results showed a linear relationship between oxidation peak current and concentration of MNA from 10 × 10−9 to 2.30 × 10−4 M (R 2 = 0.9918) with a detection limit of 1.12 × 10−9 M. The analytical performance of the fabricated sensor has been evaluated for MNA in blood samples, pharmaceutical tablets, and water samples with satisfactory results.
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