Simultaneous electrochemical detection of dopamine and uric acid based on tri-composite of poly-pyrrole and α-Fe2O3 embedded MoS2 sheets modified electrode

Abstract

Poly-pyrrole (Ppy) with α-Fe2O3 and MoS2 has served as an attractive catalyst for biosensor applications due to their versatility and structural diversity. The abnormal concentrations of dopamine (DA) and uric acid (UA) causes serious health issues in human. Hence, rapid and sensitive method requires to monitor DA and UA levels. In this esteem, a electrochemical biosensor based on Ppy-α-Fe2O3-MoS2 composite for rapid and accurate estimation of DA and UA in physiological conditions were reported. The ternary components like Ppy, MoS2 sheets, and α-Fe2O3 attribute the heterogeneous interfacial contact which leads to enhanced catalytic behavior. The Ppy-α-Fe2O3-MoS2/GCE electrocatalyst demonstrates the linear response of DA, and UA in the concentration range of 300 nM-1 mM with a detection limit of 73 nM, and 61 nM for DA and UA, respectively (S/N = 3σ/n). The sensitivity of the sensor was found to be 1.26 μA μM−1 cm2.The proposed methodology is highly selective, sensitive and cheaper to detect the DA and UA simultaneously. This approach could be utilized to employ in the fabrication of biosensor devices for practical utility in clinical diagnostics and health care centers.