Simultaneous determination of the concentrations of isoproterenol, uric acid, and folic acid in solution using a novel nanostructure- based electrochemical sensor

Abstract

A carbon paste electrode modified with 2-((7-(2,5-dihydrobenzylideneamino)heptylimino)methyl) benzene-1,4-diol (DHB) and carbon nanotubes were used to simultaneously determine the concentrations of isoproterenol (IP), uric acid (UA), and folic acid (FA) in solution. First, cyclic voltammetry was used to investigate the redox properties of the modified electrode at various scan rates. Next, the mediated oxidation of IP at the modified electrode is described. At the optimum pH of 7.0, the oxidation of IP occurs at a potential about 90 mV less than that of an unmodified carbon paste electrode. Based on the results of differential pulse voltammetry (DPV), the oxidation of IP showed a dynamic range between 10 and 6000 μmol/L, and a detection limit of 1.24 µmol/L. Finally, DPV was used to simultaneously determine the concentrations of IP, UA, and FA in solution at the modified electrode. A carbon paste electrode chemically modified with multiwall carbon nanotubes was prepared and used as a selective electrochemical sensor for the simultaneous determination of the concentrations of isoproterenol, uric acid and folic acid in solution.