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Abstract
A simple, precise, sensitive, and accurate TLC-Densitometric method has been developed and validated for simultaneous determination of the antiprotozoal drugs, metronidazole benzoate (METB), and diloxanide furoate (DF) in dimetrol® and furazole® suspensions. Moreover, the method has been optimized to determine metronidazole (MET), DF, and the antispasmodic drug mebeverine hydrochloride (MEH) in dimetrol® tablets using the same solvent system. Developing system consisting of hexane: acetone: triethyl amine (7: 3: 0.6, by volume) was found to be efficient for good chromatographic separation among the studied drugs using pre-activated silica gel 60 F254 TLC plates. Densitometric quantitation was carried out at 254 nm. The method was successfully applied for determination of MET, DF, MEH, and METB in their bulk powders and in their different dosage forms and the results obtained by applying the proposed TLC-Densitometric method showed no significant difference with those obtained by applying the reported methods.
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