Abstract
A second-derivative spectroscopic method for the simultaneous determination of polythiazide and prazosin in tablets was developed. Solutions of these tablets in 0.2 N methanolic hydrochloric acid were analyzed by measurement of the amplitudes of the positive peak at 356 nm with respect to the negative peak at 346 nm ( 2D 346,356) for prazosin, and the amplitude of the positive peak at 236 nm with respect to the baseline ( 2D 236) for polythiazide. Confirmation of the technique was established using HPLC. The use of derivative spectroscopy in this manner provides a specific, rapid and accurate determination of the binary mixture in the tested concentration range of 1–10 μg/ml for polythiazide and 1–20 μg/ml prazosin.
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