Abstract
A second-derivative spectroscopic method for the simultaneous determination of naphazoline hydrochloride and diphenhydramine hydrochloride in nose drops was developed. Solutions of this drug combination in 0.1 M hydrochloric acid were analyzed by measurement of the amplitudes of, respectively, the positive peak at 288 nm with respect to the negative peak at 282 nm, and the negative peak at 249 nm with respect to the base line. The method allows the specific, rapid and accurate determination of the binary mixture in the tested concentration range of 1–5 μg/ml for naphazoline, and 10–50 μg/ml for diphenhydramine.
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