Abstract
A derivative spectrophotometric procedure for the simultaneous determination of atenolol–amlodipine and haloperidol-trihexyphenidyl HCl in combined tablet preparations was developed. Tablet extracts of atenolol–amlodipine and haloperidol–trihexyphenidyl were prepared in 0.1 M HCl. The zero crossing point technique was used to estimate the amounts of individual drugs in the combined preparations. The results were found to be accurate, reproducible and free from interference.
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