Abstract
This paper describes a validated high-performance thin-layer chromatography (HPTLC) method for the simultaneous determination of ivermectin (IVM) and albendazole (ALB) in combined tablet dosage forms. The HPTLC separation was carried out on aluminum-backed silica gel 60 F254 layers using toluene-ethyl acetateglacial acetic acid, 6:4:0.5 (ν/ν/ν), as the mobile phase. Quantification was achieved with UV detection at 247 nm. The developed analytical method was validated according to International Conference on Harmonization guidelines in terms of parameters such as accuracy, precision, linearity, and specificity. Good linearity was observed in the concentrations ranging from 0.12 to 0.54 and 8 to 36 μg per band for IVM and ALB, respectively. The recovery study results ranged from 98% to 101% for IVM and ALB, showing the accuracy of the method. The method was successfully applied for the analysis of the drugs in laboratory-prepared mixtures and commercial tablets. The developed method is simple, precise, and ...
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