Abstract
We have investigated the regulation mechanism of the surface sialyl-Le X (sLe X) expression level in tonsillar B cells during activation. sLe X antigen became strongly positive after activation, while resting B cells were weakly positive. sLe X structures were mainly located on O-linked oligosaccharide chains of glycoprotein. Transcripts of FucT-VII and core 2 GlcNAc transferase (C2GnT) were up-regulated after activation, while those of ST3GalIV and β1→4GalT-I were expressed constitutively. However, the up-regulation of C2GnT was more dramatic than that of FucT-VII. These results suggest that sLe X expression level is regulated by C2GnT during tonsillar B cell activation.
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