Simultaneous assessment of blood pressure and respiratory function in dogs: Validation of a non-invasive telemetry method

Abstract

separate occasions with Theophylline (0, 5, 10, 20 mg/kg n=4), Clonidine (0, 0.03, 0.1, 0.3 mg/kg n=4), L-NAME (0, 10 mg/kg n=4) and Verapamil (0, 5, 10, 15 mg/kg n=4). NIBP and invasive telemetry (INV) were recorded in parallel from 1 hour pre-dose up to 5 hours post-dose. The cuff was inflated/deflated every 4 min. Respiratory parameters and ECG were recorded up to 24 hours post-dose. Numerical data are reported as percentage change compared to time matched vehicle data. Graphs show mean ± SEM for high dose only. NIBP is reported as an average of 20 min, 5 inflation/deflation cycles Respiratory parameters are reported as a 20 min average animals to explore the pharmacological interaction in response to a drug. Recent advances in technology have led to an increase in the number of non-invasive functional endpoints included in repeat dose toxicology studies, in addition to ECG1, that can be assessed using external telemetry. The aims of this validation were (a) to perform a pharmacological evaluation of an additional two parameters; non-invasive blood pressure (NIBP) and respiratory inductive plethysmography (RIP) in ECG jacketed dogs and (b) to compare systolic (SBP) and diastolic (DBP) blood pressure values recorded with NIBP to those recorded . .