Abstract
The conception “organ-on-a-chip” is a simulation of a living organism functional unit using a microfluidic device and additional technologies. Such technology can clarify some process in human body, reactions on drugs and help to create the new way of treatment without animal models. Calcific aortic stenosis is characterized as long developing disease that is more often observed among the elderly people. “Organ-on-a-chip” via microfluidic technology can simulate some process of this disease such as the calcium salts deposition in shorter time than it happens in living human body. Moreover it can explain the nature of disease. In this work we investigated the deposition of calcium salts in vessels by imitating the processes in the microfluidic chip and mathematical modelling.
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