Abstract
We model and simulate the use of ion sensitive field-effect transistor for electronic deoxyribonucleic acid (DNA) sequencing using its intrinsic molecular charge on the backbone. In this model, biological layer is treated as an ion-permeable charged membrane in solving Poisson equation. Sensor I–V characteristics are simulated, showing that the shifts of device threshold voltage respond to the DNA base-extension reaction. The simulation reveals the effects of DNA surface density, the length of a single-stranded DNA, and salt concentration on sensor performance. The simulation results demonstrate good agreement with the published experimental data, therefore, could be a good guide to actual biosensor design and fabrication.
Accepted Version
Published Version
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