Abstract
Publisher Summary This chapter discusses the simulated moving-bed (SMB) chromatography for biomolecules. This technology has a great potential for fine chemistry and the pharmaceutical industry. Because small-scale units are already available, SMBs can be operated for small-scale production as well as for very large production for very different products: enzymes orsugars, and desalting or optical isomers separations. The SMB is basically a binary separator that presents three main advantages over batch chromatography. It enables to save significant amounts of eluent. It is suggested if the product to be recovered is the first or the last eluted one in a multicomponent mixture, SMB can be used without technical modifications (only the method of determining the flow rates must be changed). In other situations, two SMB systems must usually be used in series. It enables us to maximize productivity. The value of SMBs with respect to batch chromatography is maximized for low selectivity problems or low efficiency systems. It is a continuous process that simplifies the operation and especially the connection to associated equipments (evaporation for instance).
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