Abstract
Digoxin is one of steroid as cardiac glycoside that is commonly used to treat congestive heart failure and arrhythmias. These steroids are toxic and carry a risk of digoxin medication overdose, even though the short therapeutic range of 2 ng/mL, and an excess of digoxin in blood plasma can reason for intoxication. It's crucial to gauge how much of the digoxin is present in the body. Therefore, a simple and accurate approach for closely monitoring digoxin in blood levels is required to minimalize the danger of toxicity. In this paper, the simple voltammetry method was used to detect the digoxin based on MOF derived zinc cobalt catalyst. First, ZnCo-MOF electrode material was synthesized using coprecipitation followed by calcination. The prepared materials were characterized with XRD, FTIR, XPS, FESEM, and TEM. By cyclic voltammetry (CV), Electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV) method was discovered for electrochemical response. The present sensor shows the low detection limit of 0.0046 ng/mL. The film exhibited good sensor preparation, repeatability and reproducibility as well as good stability for the determination of DIG. The practical applicability of sensor was investigated in urine real sample with acceptable recovery.
Published Version
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