Abstract
Objective Glucagon-like peptide 1 (GLP-1), one of the gut peptide hormones, has an action to induce satiety, and its effect as an anti-obesity agent is known. Recently, it has been reported that many herbal medicines have an anti-diabetic effect through inhibition of DPP-4 enzyme and inducing of GLP-1 secretion. It is therefore suggested that GLP-1 may be effective for the treatment of obesity. In this study, we report a case of male obese patients treated with herbal medicine as a GLP-1 secretagogue. Methods In this study, the patient took a fixed prescription of herbal medicine for 10 weeks and recorded his weight at each visit. Results This prescription produced significant weight loss (BMI loss>5%). In the follow-up period after two weeks, the trend of weight loss was observed continuously. Conclusion This prescription can be an alternative to ephedra herba-based obesity treatment. Keywords: obesity, herbal medicine, ephedra herba, GLP-1, Berberin, Gardenia
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