Abstract
Cytogenetic analysis of four well-differentiated malignant epithelial tumors revealed primary clones with only numerical abnormalities. The karyotypes were 49,XX,+5,+5,+7, +7, −17 50 ,XX,+5,+5,+7,+7,−17,+r in an adenocarcinoma of the lung; 47,XX, +3 47 ,XX, +5 47 ,XX,+7 in a squamous cell carcinoma of the epiglottis; 47,XX, +5 48 ,XX,+5,+10 in a squamous cell carcinoma developing in an ovarian dermoid cyst; and 52,XX,+5,+7, +8,+14,+15,+21 in a seropapillary ovarian adenocarcinoma. Also, in previously published cases exclusively numerical aberrations were much more common in highly differentiated epithelial tumors ( 22 74 ) than in moderately to low-differentiated carcinomas ( 13 281 ). Our findings and the literature data thus agree with a developmental scheme in which numerical changes, possibly reflecting an early-onset genomic instability in the tumor cells, may precede massive structural anomalies in the gradual malignization of epithelial tumors.
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