Abstract
Dopamine acts as neurotransmitter in the central and peripheral sympathetic nervous system. Determination of dopamine (DO) was performed by spectrophotometric analysis depending on the formation of new colored compound. The proposed procedure was efficient in quantitative determination of DO as pure material in pharmaceutical preparations and in urine samples. DO concentration in urine sample of patient confirms the affection with schizophrenia and the proposed procedure was used to facilitate diagnosis and followup of schizophrenic patients. It is recommended to apply the proposed procedures as routine analysis in pharmaceutical companies for quality control and in analytical laboratories to diagnose and follow up schizophrenia.
Highlights
Dopamine and dopamine derivatives were a group of biogenic amines possessing a 3,4-dihydroxy substituted phenyl ring (Figure 1)
Several methods were applied on pharmaceutical preparations containing DO.HCl or LD depending on oxidation reaction [6,7,8]
A psychiatrist will have facilities to evaluate the schizophrenic patient as a whole and to follow up the responsibility of the patient to recommended treatment according to the DO concentration present in urine sample
Summary
Dopamine and dopamine derivatives were a group of biogenic amines possessing a 3,4-dihydroxy substituted phenyl ring (Figure 1) They are considered as a type of hormones widely spread in animals and had been detected in 44 plant families [1, 2]. They seemed to be a central pharmacophore and well probably existed in future drugs, especially in those developed for psychiatry disorders and neurological activity [3] It was not until the late 1950s that dopamine was recognized as a mammalian neurotransmitter in its own right but the demonstration of its nonuniform distribution in the brain suggested that it might has a specific functional role for dopamine [4]. Several methods were applied on pharmaceutical preparations containing DO.HCl or LD depending on oxidation reaction [6,7,8]. The results obtained are of interest and are compared with these obtained by the official method
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