Similarities in effects of barbiturates and mild tranquilizers on activity in mice

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To determine the extent of similarity in the effects of barbiturates and mild tranquilizers on motor activity, mice were given pentobarbital, phenobarbital, meprobamate, and chlormezanone over a wide range of doses. All drugs increased spontaneous motor activity in photocell units at low doses and decreased activity at higher doses. The drugs resembled each other in producing the same pattern of motor impairment. Ataxia was noted at intermediate doses, and impairment of the righting reflex and ptosis were noted at higher doses. Mention was made of the possible relationship of motor impairment to changes in spontaneous activity and to changes in performance with different schedules of reinforcement.