Silver Sulfadiazine

Abstract

This chapter presents the analytical profile of silver sulfadiazine. Silver sulfadiazine appears to be active against a wide range of micro-organisms. The usual application form is a 1% w/w oil–water cream. It is stable in air but slowly becomes yellow on exposure to light. The mixing of equimolar amounts of silver nitrate and sodium sulfadiazine, both dissolved in water, results in the quantitative precipitation of silver sulfadiazine. An alternative procedure makes use of ammoniacal solutions of silver nitrate and sulfadiazine. The recrystallization of the compound can take place from 25% ammonia solution. The infrared (IR) spectrum is determined for a potassium bromide (KBr) pellet preparation of silver sulfadiazine with the use of a Beckman IR 10 spectrometer. The proton nuclear magnetic resonance (NMR) spectrum of silver sulfadiazine is recorded in dimethylsulfoxide (DMSO)-d6 containing tetramethylsilane as internal reference and with the use of a Bruker WM-300 spectrometer at frequency 300.13 MHz. Silver sulfadiazine melts with decomposition.