Abstract
Objective: The main aim of this study was to develop and evaluate the nanofiber loaded with coconut oil and silver nanoparticles (Ag NPs) for the treatment of wound healing by the electrospun method.
 Methods: The nanofibers have been created using the reduced form of silver nanoparticles and coconut oil along with Eudragit L-100 by the electrospun method. The presence of coconut oil and chemical interaction was determined by the FTIR method. XRD was made to evaluate the crystalline nature of AgNPs and Eudragit L-100. TEM was carried out to show the presence of AgNPs on the surface of nanofibers and SEM represents the diameter of the fiber. The antibacterial activity of nanofibers was carried out using a disk diffusion assay.
 Results: The diameter of the fibers was diminished by the excess of AgNPs in the fibers, while it increases by the coconut oil concentration, enhancing the nanofiber's hydrophilicity. FTIR spectroscopy was found in the range of coconut oil at 3553 cm-1for O-H stretch, 1365 cm-1, and 1240 cm-1 for the C-O stretch of ester groups. The diffraction peaks at 2θ of 38.5°, 44.6°, and 64.7°, in the XRD spectra of nanofiber, changed with silver NP affirming the total decrease of Ag salt. The bactericidal activity has been carried out between Escherichia coli and Staphylococcus aureus showing zones of inhibition of 20.0±0.2 mm and 14.8±0.4 mm, exhibiting excellent bactericidal characteristics for wound healing.
 Conclusion: The formulated nanofibers were obtained to offer protection against external agents and help in the regeneration of new tissue.
Highlights
Wounds are brought about by interruption of typical tissue-lined anatomical epithelial obstructions
Eudragit L-100/silver NPs/coconut oil nanofibers are evaluated to develop as viable disinfectant injury dressing materials
For deciding the correct convergence of Eudragit L-100 needed to shape free strands, a few preliminary trials were rehashed while changing various frameworks (e. g., voltage, stream amount, needle to gather separation mass of polymer and centralizations for silver nitrate with coconut oil) [19]
Summary
Wounds are brought about by interruption of typical tissue-lined anatomical epithelial obstructions. Wound healing is a perplexing procedure, including an assortment of occasions in various tissues and cell lines [1]. Silver nanoparticles can be consolidated into biomaterials and platforms to make polymeric nanofibers, which can help twisted recuperating through their antimicrobial and antibacterial properties [2, 3]. Nanofibers have incredible potential for an assortment of utilizations, for example, composites, filtration, biomaterials, and so forth. These fibers are regularly utilized as it is being able to expand water dissolvability, biorecognition, and biocompatibility. Main strategies used to deliver nanofibers, for example, electrospinning, centrifugal spinning, pressurized gyration, model synthesis phase separation, phase assembly [4]. In any case, electrospinning is viewed as the easiest and best methodology for nano-to microscale strands creation [5]
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