Abstract
Several neurological disorders such as Alzheimer’s disease and Parkinson’s disease have become a serious impediment to aging people nowadays. One of the efficient methods used to monitor these neurological disorders is the detection of neurotransmitters such as dopamine. Metal materials, such as gold and platinum, are widely used in this electrochemical detection method; however, low sensitivity and linearity at low dopamine concentrations limit the use of these materials. To overcome these limitations, a silver nanoparticle (SNP) modified electrode covered by graphene oxide for the detection of dopamine was newly developed in this study. For the first time, the surface of an indium tin oxide (ITO) electrode was modified using SNPs and graphene oxide sequentially through the electrochemical deposition method. The developed biosensor provided electrochemical signal enhancement at low dopamine concentrations in comparison with previous biosensors. Therefore, our newly developed SNP modified electrode covered by graphene oxide can be used to monitor neurological diseases through electrochemical signal enhancement at low dopamine concentrations.
Highlights
Dopamine is a key molecule in neurotransmissions in the central and peripheral nervous systems.dopamine is responsible for several physiological activities such as behavior, memory and movement [1,2]
Structure of the silver nanoparticle (SNP) Modified Electrode Covered by Graphene Oxide
This resulted in a non-uniform surface of the SNP modified electrode resulting in irregular electrochemical signals
Summary
Dopamine is a key molecule in neurotransmissions in the central and peripheral nervous systems. High performance liquid chromatography (HPLC) [4], immunoassay [5], spectrophotometric [6] and coulometric [7] methods have been reported to be suitable for dopamine detection Most of these techniques require complex steps and procedures, which are expensive, laborious and time-consuming. Metal materials like gold and platinum have been widely widely in biosensing applications to theirin excellence the applied applied in biosensing applications largely duelargely to theirdue excellence improving in the improving electrocatalytic electrocatalytic the electrode [11,12] Despite these gold property of theproperty electrodeof[11,12]. Graphene oxide is another beneficial alternative material choice owing to to its almost unlimited availability, good electrocatalytic property and stability.
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