Abstract
Silver(I) complexes of types [Ag(X){E(CH2C6H4Me-2)2}] [E = S, X = CF3SO3 (1), NO3 (2), ClO4 (3); E = Se, X = CF3SO3 (4), NO3 (5), ClO4 (6)] and [Ag(X){E(CH2C6H4Me-2)2}2] [X = CF3SO3, E = S (7), Se (8); X = ClO4, E = S (9), Se (10)] were prepared by reacting the diorganochalcogenides (2-MeC6H4CH2)2E [E = S (L1), Se (L2)] with the appropriate silver(I) salt in a 1:1 and a 2:1 molar ratio, respectively. The ligands and the Ag(I) complexes were characterized by multinuclear NMR spectroscopy (1H, 13C{1H}, 19F{1H}, 77Se{1H}, as appropriate), ESI+ mass spectrometry, elemental analysis and IR spectroscopy. The crystal and molecular structures of the ligand L1 and the complexes 2, 5, 7, 8 and 9 were determined by single-crystal X-ray diffraction. The molar conductivity of the reported metal complexes showed their behaviour as 1:1 electrolytes in solution, while in solid state the inorganic anionic ligand is coordinated to silver by OAg bonds. Preliminary results showed that the silver(I) complexes bearing triflato ligands have in vitro promising antiproliferative activity against the murine melanoma B16.F10 cells.
Published Version
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