Abstract
Silver binding nucleolar organizer regions (AgNOR) in normal oral mucosa (NOM), oral leukoplakia with epithelial dysplasia (ED), and oral squamous cell carcinoma (OSCC) were studied. The mean AgNOR count per nucleus increased from NOM to ED to OSCC. Tissue showing ED in oral leukoplakia and OSCC cases showed higher counts, wider scatter, and smaller size of AgNOR dots in the nuclei. The study seems to suggest that time method has some potential in distinguishing between NOM and oral leukoplakia with ED and OSCC. Studies of larger numbers are needed to arrive at more substantial conclusions.
Highlights
Leukoplakias are group of lesions of different etiologies and most common potentially malignant oral lesions
Oral squamous cell carcinoma (OSCC) is a malignant neoplasm arising from mucosal epithelium
OSCC is a malignant neoplasm of oral mucosal epithelium
Summary
Leukoplakias are group of lesions of different etiologies and most common potentially malignant oral lesions. Epithelial dysplasias (ED) are malignant changes, seen in leukoplakias [1]. Oral squamous cell carcinoma (OSCC) is a malignant neoplasm arising from mucosal epithelium. No clear markers have evolved to distinguish them [2]. Patterns of nucleolar organizer regions (NOR) as visualized by silver staining (AgNOR) vary with different cell cycle stages. These are replicatory markers useful in diagnosing oral leukoplakia [3]
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