Silk Fibroin Hydrogel for Pulse Waveform Precise and Continuous Perception.

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Precise and continuous monitoring of blood pressure and cardiac function is of great importance for early diagnosis and timely treatment of cardiovascular diseases. The common tests rely on on-site diagnosis and bulky equipments, hindering early diagnosis. The emerging hydrogels have gained considerable attention in skin bioelectronics by virtue of the similarities to biological tissues and versatility in mechanical, electrical, and biofunctional engineering. However, hydrogels should overcome intrinsic issues such as poor mechanical strength, easy dehydration and freezing, weak adhesiveness and self-recovery, severely limiting their precision and reliability in practical applications. Here, silk fibroin hydrogels are developed as resistive sensors for pulse waveform monitoring. The silk fibroin hydrogel is simultaneously transparent, extremely stretchable, extra tough, adhesive, printable, and environmentally endurable. The silk fibroin hydrogel is also conductive with high sensitivity, short self-healing time, highly repeatable and reliable response, meeting the requirements for wearable sensors for continuous monitoring. The sensors with silk fibroin hydrogel present high-quality and stable waveforms of radical and brachial pulses with high precision and rich features, providing physiological signals of blood pressure and cardiac function. The sensors are promising for personalized health management, daily monitoring and timely diagnosis.