Abstract
(A) The Winkler reaction,4 the addition of cyanide to carbonyl, which allows the preparation of cyanohydrin, is one of the old carbon– carbon bond-forming reactions. Heydari et al. carried out the Winkler reaction by using HClO4–SiO2 to act as a highly effective catalyst.5 (B) Xanthenes and benzoxanthenes are cited as active oxygen heterocycles possessing anti-bacterial, anti-inflammatory, and antiviral properties. They are also utilized in photodynamic therapy.6 Bigdeli et al. and Das et al. synthesised these molecules by using HClO4–SiO2 as catalyst.7,8 (C) Quinolines are useful as drugs and pharmaceuticals. HClO4–SiO2 can be applied for the development of simple, convenient, and highyielding syntheses.9 (D) The Mannich reaction10 is an important cabon–carbon bond forming reaction and used for the synthesis of b-amino carbonyl compounds, which are important synthetic intermediates for various pharmaceuticals and natural products. Bigdeli et al. applied HClO4– SiO2 in a one-pot, three-component Mannich reaction.11 (E) HClO4–SiO2 can be applied for the synthesis of 1, 4- dihydropyridines. 12
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
