Silent transmission of “COVID-19”: A major concern

Abstract

“Coronavirus disease 2019 “(COVID-19)” has been proclaimed as a public health exigency of global scope by “World Health Organization” and is the latest threat to universal health. Despite of manifesting imperceptible clinical symptoms, asymptomatic carriers of the disease are known to be infectious. The prevalence of “COVID-19” is rising persistently, despite meticulous global confinement and quarantine endeavors. An important element in the devastating transmissibility potential of “COVID-19” is the high titre of virus in oropharynx in the initial progression of disease. On the contrary influenza virus has low titres in upper respiratory tract than lower respiratory tract. Therefore, making the symptom-based assessment strategies less effectual in case of “SARS-CoV-2” According to recent reports, symptomless population along with the individuals with mild disease, are radical transmitters in the proliferation of “COVID-19”. The phenomenon of Viral shedding emphasizes the reasons of asymptomatic patients being rapid transmitters in “SARS-CoV-2” than “SARS-CoV-1”. The significant role of incubation span, cycle threshold values, serial interval cannot be overlooked in asymptomatic transmission. This pandemic is an absolute reminder of the existing challenge posed by the virulent pathogen on modern medicine. Thus, we intend to comprehensively elaborate various outlooks on the asymptomatic spread of “SARS-CoV-2”, including the pathophysiology, viral shedding, cycle threshold, serial interval, incubation span, herd immunity, inefficient testing, prevention and prospective treatment of “COVID-19”.