Abstract
Silent clusters - speak up!
Highlights
Microorganisms have provided mankind with a multitude of useful compounds ranging from industrial enzymes to anti-cancer compounds and antibiotics
Despite the complexity of the bioactive secondary metabolites produced by microorganisms, several pathways are conserved at the modular level
It is believed that the reason for the ‘non-discovery’ of these potential novel compounds is largely because the genes are not expressed during normal laboratory cultivation; so-called silent gene clusters
Summary
Microorganisms have provided mankind with a multitude of useful compounds ranging from industrial enzymes to anti-cancer compounds and antibiotics. Such genome mining processes have revealed that the bioactive potential in numerous microorganisms is likely much higher than previously discovered by bioassay-guided fractionation. It is true for several groups of Gram-negative prokaryotes (Still et al, 2014) that hitherto have not been thought of as useful producers of bioactive compounds.
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